Definition from macmillandictionary.com
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the West Coast route
a bus/shipping/trading route
It’s a good idea to plan your route before you leave.
We took an alternative route to the hotel.
The most direct route from the house to the school is through the town centre.
The tunnel is the route taken by most drivers.
The sea was the most direct route between the two cities.
the route to success/happiness/disaster
I’ll need to think carefully before deciding what route to take next.
We turned off Route 66 onto a remote road.