Definition from macmillandictionary.com
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a profound change in the climate of the Earth
The difference between the beginners and the intermediate class was profound.
This is a scientific discovery of profound significance.
My grandfather’s death had a profound effect on my father.
Most of the divorced parents we interviewed said they had experienced guilt and a profound sense of failure.
Kafka’s profound insights into human experience
She was profoundly influenced by Schulz.